Elementary osmotic pump eop rosenelson pump was further simplified in the form of elementary osmotic pump 20, 52, which made osmotic delivery as a major method of achieving controlled drug release. Controlled osmotic drug delivery, elementary osmotic pump, nifedipine, metoprolol tartrate, semipermeable membrane. We designed an elementary osmotic device using mp as both active ingredients and also as the osmotic agent. The elementary osmotic pump is a new delivery system for drugs or other active agents. Watch this short video for an overview of the alzet technology, benefits and applications. Development and characterization of elementary osmotic pump. An effective device for delivery of poorly watersoluble drugs. Higuchi leeper pump, higuchi theeuwes pump, elementary osmotic pump etc. Single chamber osmotic pump elementary osmotic pump. Weight loss after immersing in various mediums, water soluble protein fraction, loss on drying, and formaldehyde residue were investigated. The pump consists of an osmotic core containing the drug, surrounded by a. Osmotic pumps contain a drug semi permeable membrane. Factors affecting the release of nifedipine from a swellable elementary osmotic pump.
The pump consists of an osmotic core containing the drug, surrounded by a semipermeable membrane with a delivery orifice. Floating elementary osmotic pump tablet feopt for controlled delivery of diethylcarbamazine citrate. Osmotic pumps release drug at a rate that is independent of the ph and hydrodynamics of the dissolution medium. Characterization of crosslinked hard gelatin capsules for. The results of these tests are approximations of the real system with. The formulations comprise of a core tablet coated with a semi. May 26, 2017 elementary osmotic pump semi permeable membrane core delivery orifice major method of achieving controlled drug release it is fabricated as a tablet coated with semi permeable membrane, usually cellulose acetate when this coated tablet is exposed to an aqueous environment, the osmotic pressure of the soluble drug inside the tablet. In the 1970s, theeuwes 1975 introduced the elementary osmotic pump eop and brought forward its basic theory. The drug is forced out of an orifice in the device by the osmotic pressure generated by the device. Formulation design and characterization of an elementary. The elementary osmotic pump eop was developed by alza in 1974, and was the first practical example of an osmotic pump based drug release system for oral use. On the contrary, in the drcs osmotic pump tablet drcopt, the lag time was increased to achieve.
The osmotic drug delivery systems suitable for oral administration. The alzet mini osmotic pump model 2001 delivers solutions continuously for 7 days without the need for external connections or frequent handling of animals. Recent advances include development of the controlled porosity osmotic pump, and systems based on asymmetric membranes. Rose and nelson pump was further simplified in the form of elementary osmotic pump. Feb 05, 2015 list of contents introduction advantages of osmotic drug delivery system disadvantages of osmotic drug delivery system principle of osmosis basic components of osmotic pump factors affecting release of medicament from osmotic dds osmotic pumps first osmotic pump three chamber rosenelson osmotic pump elementary osmotic pump eop controlled.
This membrane contains an orifice of a critical size through which the drug is delivered. What is the abbreviation for elementary osmotic pump. The osmogens used in this study did not alter the physicochemical properties of. Formulation and evaluation of controlled release tablets of. Read elementary osmotic pump for indomethacin, journal of pharmaceutical science on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at. Elementary osmotic pump 6,7 in 1975, the major leap in osmotic delivery occurred as the elementary osmotic pump for oral delivery of drugs was introduced. In the traditional osmotic pump tablets opts, the lag time was always minimized. The present work was aimed to formulate and evaluate osmotic pump delivery system of amlodipine besylate using two osmogens nacl and kcl by wet granulation method. Elementary osmotic pump eop2225 rosenelson pump was further simplified in the form of elementary osmotic pump, which made osmotic delivery as a major method of achieving controlled drug release. Jan 28, 2019 the objective of this study was to characterize the crosslinked hard gelatin capsules hgcs for use as a structural assembly of elementary osmotic pumps eop. Effervescent elementary osmotic pump modified osmotic pump 1. Delivery of drug from osmotic pumps can be designed to follow true zeroorder kinetics.
The aim of present study was to design and evaluate an elementary osmotic pumpbased drug delivery system for controlled release of metformin and glipizide. Elementary osmotic pump, journal of pharmaceutical science. Pdf factors affecting the release of nifedipine from a. Schematic diagram of elementary osmotic pump delivery orifice 8. Read elementary osmotic pump for indomethacin, journal of pharmaceutical science on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Development and evaluation of oral elementary osmotic pump. Development and evaluation of elementary osmotic pump for. Elementary osmotic pump eop is a unique extended release er drug delivery system based on the principle of osmosis. Study of drug release from an elementary osmotic pump. Elementary osmotic pump pda journal of pharmaceutical.
The batches were formulated by using wet granulation. Nelson pump,1 higuchileeper pump,2,3 elementary osmotic pump tablet eopt,4 and pushpull system. The elementary osmotic pump tablet is a core tablet coated by semipermeable membrane with a microorifice drilled on the surface. A novel osmotic pump tablet using core of drugresin. Elementary osmotic pump for indomethacin, journal of. Request pdf development and evaluation of oral elementary osmotic pump tablets for ropinirole hydrochloride the objective of the present study was to develop a sustained release once a day. Optimization and development of swellable controlled porosity. A method for the preparation of vin elementary osmotic pump tablet was obtained by adding organic acid additives to increase vin solubility. Normally, the elementary osmotic pump delivers 6080% of its contents at a constant rate, and there is a short lag time of 3060 min as the system hydrates before zero order delivery from the elementary osmotic pump is obtained. An oral osmotic pharmaceutical delivery system comprises a highly watersoluble drug exhibiting an erratic or an incomplete release profile when formulated in a elementary osmotic pump delivery system and at least one release enhancing agent. Leeper pumps, the alzet and osmet systems, the elementary osmotic pump, and the pushpull system. The elementary osmotic pump is a new delivery system for drugs which delivers the drug by an osmotic process at a controlled rate. Osmoticcontrolled release oral delivery system wikipedia. Characterization of crosslinked hard gelatin capsules for a.
Diethylcarbamazine citrate dec was chosen as a model drug. Elementary osmotic pumps are well known for delivering moderately soluble drugs at a zeroorder rate. Formulation and evaluation of osmotic pump delivery of oxybutynin. The intention of this design is to take advantage of the. The delivery rate from this system in uitro and in the gi tract of dogs was found to be equal. The basic oros system, the elementary osmotic pump eop, was. Seop tablets were prepared by compressing the mixture of micronized drug and excipients into convex tablets. The design and formulation of an osmotic pump tablet determines the release rate of the drug and are based on exhaustive and expensive physicochemical testing of the systems characteristics. Hgcs were crosslinked in formaldehyde vapor for 6, 12, and 24 h. A novel timecontrolled system based on elementary osmotic pump tablet containing a drugresin complexes drcs core is presented. Osmotic pump tablets offer highly predictable and programmable delivery of drugs into solution, ready for absorption. It delivers the active agent by an osmotic process at a controlled rate. Application of hotmelt extrusion technology for designing an elementary osmotic pump system combined with solid dispersion for a novel poorly watersoluble antidepressant. It has the ability to minimize the amount of the drug, accumulation and.
Formulation aspects in development of controlled porosity. Various techniques available for preparation of osmotic drug delivery system include push pull osmotic pump, osmotic brusting osmotic pump, liquid oral osmotic system, sandwiched osmotic tablets, delayed delivery osmotic device, monolithic osmotic system and controlled. Optimization and development of swellable controlled. The drug release mechanism of mots is different from that of an elementary osmotic pump tablet eop or a pushpull osmotic pump tablet ppop nokhodchi et al. Formulation and evaluation of osmotic pump delivery of. The simplest design of elementary osmotic pump consists of an osmotic.
Abstract the elementary osmotic pump is a new delivery system for drugs or other active agents. Hiren and vaishnavi, international journal of bioassays 6. A novel osmotic pump tablet using core of drugresin complexes for timecontrolled delivery system. Preparation and in vitro and in vivo evaluation of vinpocetine vin elementary osmotic pump eop formulations were investigated. The historical development of osmotic systems includes seminal contributions such as the rosenelson pump 16, the higuchileeper pumps 17, the alzet and osmet systems 18, the elementary osmotic pump 19, and the pushpull or gitsr system 20. Application of hotmelt extrusion technology for designing an. The osmotic principle was first applied to this use by rose and nelson in 1955 using an implantable pump. Formation of complex was confirmed by differential scanning calorimetry and fourier transform infrared spectroscopy. Single and multichamber osmotic pump 3 single chamber osmotic pump. Such a device, called the elementary osmotic pump eop, was first described by theeuwes and higuchi 1975.
Factors affecting the release of nifedipine from a swellable. The eop was developed by alza undre the name oros for controlled release oral drug delivery formulations. The feopt consisted of an osmotic core dec, mannitol, and hydrophilic polymers coated with a semipermeable layer cellulose acetate and a gas. European journal of pharmaceutics and biopharmaceutics. Eop abbreviation stands for elementary osmotic pump. Elementary osmotic pump semi permeable membrane core delivery orifice 1. A novel timecontrolled release system based on drugresin. Factors affecting the release of nifedipine from a.
Osmotic drug delivery system as a part of modified release. Thus, in our current studies, we have developed a floating elementary osmotic pump tablet feopt of dec using the principle of elementary osmotic pump by incorporating hydrophilic polymers in the core compartment. Alza corporation of the usa was first to develop an oral osmotic pump and since today, they are the leaders in the field of osmotic pump drug delivery systems with a technology named oros. Alzet osmotic pumps implantable infusion pumps for. Pdf osmotically controlled oral drug delivery systems. A porous osmotic pump based drug delivery system can be designed for controlled release of highly watersoluble drug oxybutynin. Formulation and evaluation of controlled release tablets. Schematic diagram of an elementary osmotic pump a and a pushpull osmotic pump. Drug release from the system, called swellable elementary osmotic pump seop, is through a delivery orifice in the form of a very fine dispersion ready for dissolution and absorption. Osmotic tablet of atomoxetine hcl was formulated using various types of osmogens fructose, mannitol and sodium chloride and concentration 20%, 40% and 60%.
Osmoticcontrolled release oral delivery system the pharma. Various patents available for osmotic drug delivery system like rosenelson pump, higuchileeper pump, higuchitheeuwes pump and elementary osmotic pump. Centre for biopharmaceutics and pharmacokinetics, university college of pharmaceutical sciences, kakatiya university, warangal, andhra pradesh, india elementary osmotic pump eop for controlled release of phenyl propanolamine hydrochloride ppa was developed based on osmotic technology using an osmogen, sodium chloride. Osmotic systems for controlled drugdelivery applications are well established, both in human pharmaceuticals and in veterinary medicine. The objective of this study was to characterize the crosslinked hard gelatin capsules hgcs for use as a structural assembly of elementary osmotic pumps eop. The historical development of osmotic systems includes development of the rosenelson pump, the higuchileeper pumps, the alzet and osmet systems, the elementary osmotic pump, and the pushpull system. Elementary osmotic pump delivers 6080% of its contents at a constant rate, and there is a short lag time of 3060 min as the system hydrates before zero order delivery from the elementary osmotic pump is obtained.
Elementary osmotic pump eop it works on the same mechanism as the impala table pumps it is simplest possible form of osmotic pump as it. Preparation and in vitroin vivo evaluation of vinpocetine. Pdf floating elementary osmotic pump tablet feopt for. The present work investigates the feasibility of the design of a novel floating elementary osmotic pump tablet feopt to prolong the gastric residence of a highly watersoluble drug. Elementary osmotic pump eop b multiple chamber osmotic pump 1. Keyphrases 0 delivery systems, drugelementary osmotic pump. Almost 20 years later, theeuwes refined the concept to introduce the elementary. Single osmotic pump elementary osmotic pump eop controlled porosity osmotic pump cpop osmotic bursting osmotic pump. Development and evaluation of elementary osmotic pump for the. It was introduced to the market in the early 1980s in osmosin indomethacin and acutrim phenylpropanolamine, but unexpectedly severe issues with gi irritation and cases of gi perforation led to the withdrawal of osmosin. Recent advances include the development of the controlled porosity osmotic pump. The historical developments of osmotic systems include seminal contributions such as the rosenelson pump 4, the higuchileeper pumps 5, the alzet osmotic pump 6, the elementary osmotic pump eop 7 and the pushpull osmotic pump 8.
However, the generic eop is only suitable for the delivery of moderately solubility drugs. Alzet osmotic pumps have been a part of successful research for over 40 years. The elementary osmotic pump is a new delivery system. Study of drug release from an elementary osmotic pump tablet. Effect of polyethylene glycol on cellulose acetate films. Development and evaluation of elementary osmotic pump of. The main components of the eop are as osmotic core. Various techniques available for preparation of osmotic drug delivery system include push pull osmotic pump, osmotic brusting osmotic pump, liquid oral osmotic system, sandwiched osmotic tablets, delayed. The objective of the present study was to develop elementary osmotic pump tablets containing flurbiprofen using an inclusion complex. However, no such type of osmotic pump has been developed separately for watersoluble drugs like diethylcarbamazine citrate dec.
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